The data package and code are part of the manuscript:
ZEB1-dependent modulation of fibroblast polarization governs inflammation and immune checkpoint blockade sensitivity in colorectal cancer.
Constantin Menche1,2,#, Harald Schuhwerk3,#, Isabell Armstark3, Pooja Gupta4, Kathrin Fuchs3, Ruthger van Roey3, Mohammed H. Mosa1,2, Anne Hartebrodt5, Yussuf Hajjaj3, Ana Clavel Ezquerra3, Manoj Kumar Selvaraju4, Carol I. Geppert6, Stefanie Bärthel7,8,9, Dieter Saur7,8,9,10, Florian R. Greten1,2,11,12, Simone Brabletz3, David B. Blumenthal5, Andreas Weigert2,11,12,13, Thomas Brabletz3,*, Henner F. Farin1,2,11,12,§,* and Marc P. Stemmler3,§,*
1Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany
2Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt/Main, Germany
3Department of Experimental Medicine 1, Nikolaus-Fiebiger Center for Molecular Medicine, FAU Erlangen-Nürnberg, Germany
4Core Unit for Bioinformatics, Data Integration and Analysis, Center for Medical Information and Communication Technology, University Hospital Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany
5Department Artificial Intelligence in Biomedical Engineering (AIBE), FAU Erlangen-Nürnberg, Erlangen, Germany
6Institute of Pathology, University Hospital Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany
7Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany
8Chair of Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technische Universität München, Munich, Germany
9Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.
10Department of Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
11German Research Center (DKFZ), Heidelberg, Germany
12German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Frankfurt am Main, Germany
13Institute of Biochemistry I, Goethe University, Frankfurt am Main, Germany.
#,§equal contribution
* correspondence to: T. Brabletz: thomas.brabletz@fau.de, H.F. Farin: h.farin@georg-speyer-haus.de, or M.P. Stemmler: marc.stemmler@fau.de